论文标题:女性皮肤屏障功能相关参数与部位、皮肤类型的相关性研究
Study on the Relationship between the Parameters of Skin Barrier Function and Anatomic-site, Skin Type
论文作者
论文导师 蒋献,论文学位 硕士,论文专业 皮肤病与性病学
论文单位 四川大学,点击次数 926,论文页数 47页File Size2424K
2007-05-09论文网 http://www.lw23.com/lunwen_217992/
skin;; water capacitance ;; sebum secretion;; PH values;; TEWL;; non-invasive evaluation
皮脂、水分、PH值和透皮水丢失(transepidermal water loss，TEWL)可以间接反映皮肤的屏障功能，是皮肤健康与否的重要指标。而且这些参数往往是相互影响的。现代无创皮肤检测技术的迅速发展，为我们全面了解皮肤的生理状况提供了技术支持。 目的：采用无创检测技术量化评价成年健康女性皮脂、水分、PH值及TEWL，并分析其与年龄、部位和皮肤类型的关系，了解女性正常的皮肤生理状况。 方法：对55名以室内工作为主，年龄20-40岁的汉族女性健康志愿者采用皮肤油脂水分PH值测量仪(Courage Khazaka，Germany)和皮肤水分流失测试仪TEWAMETER(?)TM300(Courage Khazaka，Germany)检测前额、眼睑、颊前、颊侧、前臂屈侧正中5个部位的皮脂、水分、PH值和TEWL；根据皮肤类型将志愿者分为干性皮肤、油性皮肤、中性皮肤、混合性皮肤四组，根据乳酸刺激试验将志愿者分为阳性组与阴性组，观察组间各参数的差异。另外对52名外观正常的疑似敏感性皮肤患者进行面部皮肤水分的测量和乳酸刺激试验。 结果：皮脂、水分、PH值、TEWL值随不同身体部位而变化，以皮脂最为明显。不同皮肤类型(干性、油性、中性、混合性)的皮脂、水分、PH值也存在差异，其中以皮脂的差异最大(P＜0.01)。皮肤较敏感的(乳酸刺激试验阳性)其TEWL较高而水含量较低。皮脂与水分呈正相关(P＜0.05)，与PH值呈负相关(P＜0.05)；TEWL与水分成负相关(P＜0.01)。 结论：皮脂、水分、PH值与部位、皮肤类型相关，且各参数之间可以相互影响。TEWL反映皮肤屏障功能，比其他参数更加敏感。利用无创技术可以了解皮肤正常的生理状态，通过监测皮肤的这些参数掌握健康皮肤或疾病的发展。
The skin sebum secretion, water capacitance, pH values and TEWL always be used to describe the function of stratum corneum barrier, and they are the parameters standing for skin health. The stabilization of barrier depends on a balance between different parameters. We will study the physiological condition of the skin depended on the development of Noninvasive bioengineering methods. Objective: To quantitatively evaluated skin sebum secretion, water capacitance, PH values and TEWL of healthy female volunteers with non-invasive measurement and analyze their relationship between anatonic-sites and skin type. Methods: The skin sebum secretion, water capacitance, PH values ,TEWL in the forehead, eye rims, cheek front, cheek side and flexible forearm for 55 healthy female volunteers in Chengdu aged from 20 to 40 years old was measured using the Sebumeter~(?)/Corneometer~(?)/Skin-pH-Meter~(?) (Courage Khazaka, Germany) and Tewameter~(?) TM300(Courage Khazaka, Germany). Divided the 55 volunteers into 4 groups according to skin type, and 2 groups(the positive and negative group) according to the response of lactic acid stinging test. Other 52 volunteers with suspicious sensitive skin accepted water capacitance measurement and lactic acid stinging test. Results: The skin sebum secretion, water capacitance, PH values and TEWL of measured anatomic-sites and skin type were different, especially the skin sebum secretion. The group that positive to lactic acid stinging test had higher TEWL measurement and lower water capacitance measurement. Skin sebum secretion and water capacitance were statistically positively relevant (P < 0.05), but the skin PH values and sebum secretion, TEWL and water capacitance were statistically negatively relevant(P < 0.05). Conclusion: Non-invasive evaluation can explore the changes of skin sebum secretion, water capacitance, PH values in different anatomic-sites and skin type, quantitatively reveal their relevance. TEWL was more sensitive than other parameters to reflect the skin barrier function. We can study the physiological condition of the skin using Noninvasive bioengineering methods.
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