论文标题:通痹颗粒治疗类风湿性关节炎的实验研究
A probe into synergetic effect and mechanism of Sijunzi decoction and Fluconazole in treating infected mice with deep-seated candidiasis
论文作者 朱晓明
论文导师 马骥,论文学位 硕士,论文专业 方剂学
论文单位 辽宁中医学院,点击次数 108,论文页数 22页File Size1058k
2001-04-01论文网 http://www.lw23.com/lunwen_243598527/ 通痹颗粒,类风湿性关节炎(RA),佐剂性关节炎(AA),肿瘤坏死因子α(TNF-α)
Tongbi Granule (TBG);Rheumatoid arthritis(RA); Adjuvant arthritis(AA);Tumornecrotic factor α(TNF-α)
目的：探索通痹颗粒治疗类风湿性关节炎（RA）的作用机理。方法：以佐剂性关节炎（AA）大鼠为研究对象，观察通痹颗粒对AA大鼠原发性和继发性病变以及T淋巴细胞亚群和血清TNF-α的影响。并与雷公藤多甙片进行对比。结果：通痹颗粒对AA大鼠的原发性和继发性病变有明显的预防和治疗作用。明显降低血清TNF-α，调节T淋巴细胞亚群的功能紊乱。结论：通痹颗粒对AA大鼠的治疗是通过改善T淋巴细胞亚群分布及细胞免疫功能起作用。
Objective: To explore the therapeutic mechanism of Tongbi Granule(TBG)in treating rheumatoid arthritis(RA). Methods: Ve studied the animal model of adjuvant arthritis(AA) in rats, and observed the effects of TBG on T Lymphocyte subpopulat ion , TNF-α , the primary and secondary lesions of AA in rats. Tripterygium wilfordi polyglycosidium tablet was used in the control group. Results: TBG had obviously prevent and treatable function on the primary and secondary lesions of AA in rats. It could reduce obviously the level of serum TNF-α and make the function of T Lymphocyte subpopulation normal. Conclusion: The TBG acted on AA in rats by improving distribution of T Lymphocyte subpopulation and the function of cellular immunity.
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