论文标题:温阳益心安神法防治心房颤动的基础研究
FUNDAMENTAL STUDY ON ATRIAL FIBRILLATION PREVENTED AND TREATED BY THE THERAPY OF WARMING YANG-INVIGORATINGHEART AND TRANQUILIZING
论文作者 郑德俊
论文导师 曹洪欣,论文学位 硕士,论文专业 中医基础理论
论文单位 黑龙江中医药大学,点击次数 103,论文页数 37页File Size2459k
2001-04-01论文网 http://www.lw23.com/lunwen_27888782/ 心房纤颤, 中医药疗法, 动物模型, 超声心动图
Atrial fibrillation,Medicinal herb therapy,Animal model,Ultrasound cardiogram
本文通过对30例房颤患者发病及治疗过程中证候的动态观察，提出心阳虚弱、心气亏损是本病的基本证候，温阳益心安神法是治疗房颤的基本治则；运用此法能明显改善房颤患者临床症状，提高生命质量，并对阵发性房颤效果显著，总有效率为70％。另外，对其中10例运用超声心动图新技术，克服了房颤患者难以准确测量左心舒张功能的障碍，客观地评价了治疗前后左心舒张功能情况，证实了运用温阳益心安神法能改善左心舒张功能，与临床症状的改善相一致。为进一步探讨温阳益心安神法治疗房颤的作用机理，采用药物攻击小鼠引起心房纤颤的动物模型，并用中药保护的方法，观察了小鼠的心电及心房、心耳超微结构。结果显示：温阳益心安神法能缩短药物攻击所致房颤持续时间；明显减缓房颤所致超微结构损伤，具有组织细胞保护作用。
Through observing the dynamic syndrome of 30 patients with atrial fibrillation (At) in the process of pathogeny and therapy, we put forward that the deficiency of heartyang and heart-qi is the basic symptom, that the therapy of warming-yang and invigorating-heart and tranguilizing is the basic way to cure Af. By using that therapy, we can alleviate the symptoms of the patients with Af and improve their quality of life,especially to patients with paxoxysmal atrial fibrillation(PAF).The total effective rate is 70%. Besides,by adopting the new technology of UCG,we conquered the difficulty in marking accurately the left ventricular diastolic function and estimated objectively left ventricular(LV) diastolic funtion of 10 patients before and after treating.The result testified that the therapy can reduce LV diastolic dysfunction of patients with Afwhich is accorded with improvement of symptoms. In order to. clarify further the mechanism of treating Af by this method,we observed the ECG and ultrastructure of cardiac atrium and auricula of Af mice model whose Af was caused by drugs and protected by Chinese drugs in advance.The result shows that the therapy of warming yang-invigorating heart and tranquilizing can cut down the Af time and alleviate the damage of ultrastructure caused by Af and protect histocyte.
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