论文标题:糖肾康对早期糖尿病肾病血流动力学和血管紧张素Ⅱ的影响研究
Influence to Angiotensin Ⅱ Level of Tangshenkang in Early Diabetic Nephropathy
论文作者 韩吉淼
论文导师 程益春,论文学位 博士,论文专业 中医内科学
论文单位 山东中医药大学,点击次数 85,论文页数 72页File Size3824k
2003-04-20论文网 http://www.lw23.com/lunwen_666653487/ 糖肾康;糖尿病肾病;肾脏血流动力学;血管紧张素Ⅱ
Tangshenkang;Renal hemodynamic;Angiotensin Ⅱ;Diabetic nephropathy
目的 本实验旨在研究具有健脾补肾、祛瘀泄浊作用的纯中药制剂糖肾康对糖尿病肾病早期肾血流动力学的作用以及对血管紧张素Ⅱ的影响，探寻糖肾康防治糖尿病肾病的机制，为临床应用提供可靠的实验依据。方法 用链脲佐菌素(STZ)腹腔注射所致的糖尿病大鼠作为动物模型，予以糖适平联合洛汀新作为阳性对照组，治疗8周，观察大鼠的肾脏血流动力学的改变和血管紧张素Ⅱ水平的变化以及血糖、血脂、尿微量白蛋白、糖基化血红蛋白等指标的前后改变。结果 实验表明糖肾康能显著改善糖尿病肾病大鼠早期的肾脏血流动力学的异常，降低异常升高的血管紧张素Ⅱ水平，减少尿微量白蛋白的排泄，减轻肾损害，同时有效地降低血糖、血脂和糖基化血红蛋白。结论 糖尿病肾病早期存在肾脏高灌注和高滤过，血管紧张素Ⅱ的升高是糖尿病肾病早期肾脏血流动力学异常的重要原因，糖肾康能降低升高的血管紧张素Ⅱ水平，有效地防治糖尿病肾病，显示出良好的整体效应，提示降低血管紧张素Ⅱ水平，改善肾脏血流动力学可能是糖肾康防治糖尿病肾病的主要机制之一。
Objective The objective of this experiment is to study the action to renal hemodynamic and the influnence to Angiotensin II level of Tangshenkang which is pure herb formula and which has the function of strengthing the spleen and kidney and relieving turbid and removing blood stasis in early diabetic nephropathy. And we also research the mechanism of Tangshenkang to prevent and cure diabetic nephropathy to provide experimental evidence for the clinic medicine. Methods The STZ-induced diabetic rats were made as experimental model, and Gliquidon and Lotensin were used as positive control drugs. The treatment time is eight-week long, we observed the change of renal hemodynamic, and also the level of angiotensin II which influence renal hemodynamic, urea-microalbumin, blood glucose, cholesterol, triglyceride, and HbA,c. Results The results show that Tangshenkang has good therapeutic in early DN. It can improve the renal hemodynamic and renal function markedly. Also, it can decrease the urea-microalbum. The level of angiotensin II descended. At the same time, the blood glucose, blood lipid, and HbA,c were all improved effectively. Conclusion At last, we concluded that the reduction of angiotensin II may be an important factor in the abnormal changes of renal hemodynamic. Tangshenkang can effectively prevent and cure DN and manifests good entirety effect. Improving the levels of angiotensin II and so to improve renal hemodynamics may be one of principal mechanisms of the prophylactico-therapeutic action of Tangshenkang on DN.
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