论文标题:固冲止血汤治疗气虚血瘀型功血出血期的临床研究
The Clinical Study of Guchong Zhixue Decoction in Treating Hemorrhagic Period of Dysfunctional Uterine Bleeding with Qi Deficiency and Blood Stasis Syndrome
论文作者 鹿鸣瑞
论文导师 刘金星,论文学位 硕士,论文专业 中医妇科学
论文单位 山东中医药大学,点击次数 101,论文页数 38页File Size2042k
2003-04-20论文网 http://www.lw23.com/lunwen_69377912/ 固冲止血汤;气虚血瘀;功能失调性子宫出血;临床研究
Guchong Zhixue Decoction;Qi deficiency and Blood stasis;Dysfunctional uterine bleeding;Clinical study
目的：运用中西医理论，从理论及临床方面对固冲止血汤治疗气虚血瘀型功血出血期的疗效及止血机理进行系统探讨。方法：将60例气虚血瘀型功血患者随机分为治疗组(30例，口服固冲止血汤)及对照组(30例，口服益宫止血口服液)观察止血疗效、治疗前后临床症状改善情况、子宫内膜厚度、凝血酶原时间及部分凝血活酶时间、血清Ca~(2+)水平、内分泌激素、经血血清PGE_2及PGF_(2α)、子宫内膜ER、PR含量等的变化。结果：固冲止血汤治疗止血疗效总有效率为93.3％，显著优于对照组(P＜0.05)。治疗前两组在临床表现、子宫内膜厚度、凝血酶原时间及部分凝血活酶时间、血清Ca~(2+)水平、经血血清PGE_2及PGF_(2α)、子宫内膜ER、PR含量等方面差异均无显著性(P＞0.05)；治疗组治疗后在改善临床症状、子宫内膜的厚度、凝血酶原时间及部分凝血活酶时间、血清Ca~(2+)水平、经血血清PGE_2及PGF_(2α)、子宫内膜ER、PR含量等方面，与疗前相比均有显著性差异(P＜0.05或P＜0.01)，且治疗组与对照组疗后两组间比较亦有显著性差异(P＜0.05)。结论：固冲止血汤对于气虚血瘀型功血出血期具有良好的止血作用，并能显著改善伴随症状。其止血作用可能是通过促凝血、提高血钙水平、调节前列腺素比例、改善子宫内膜ER、PR含量来实现的。
Objective: To explore systematically the effect and the hemostasis principle of Guchong Zhixue Decoction (GCZXD) in treating dysfunctional uterine bleeding (DUB) with Qi deficiency and Blood stasis syndrome based on the theoretical and clinical research under the guidance of traditional and western medical theory. Method: 60 patients were divided randomly into test group (30 cases, treated with GCZXD) and control group (30 cases, treated with Yigong Zhixue Mixtures). The hemostasis effect, the improvements of clinical symptoms and the density of endometrium, prothrombrn time (PT) and activated partial prothrombrn time (APTT), the serum level of Ca2+, serum sex hormone, the concentrations of PGE2 and PGF2α, the levels of endometrial ER and PR were observed. Results: GCZXD could improve clinical symptoms of patients obviously, and the difference was significant compared to control group. Meanwhile, the density of endometrium and PT, APTT were decreased, the serum level of Ca2+ was increased compared to that of the pretherapy, and the difference was significant compared to control group. It showed that the efficiency of test group is significantly superior to that of control group in adjusting PGE2/PGF2α and ER/PR. Conclusion: GCZXD is an effective recipe in treating DUB with Qi deficiency and Blood stasis syndrome. The effect may be achieved through the operation of promoting cruor, improving the serum level of Ca2+, adjusting the concentrations of PGE2, PGF2α and the levels of endometrial ER, PR.
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