论文标题:周细胞在心肌纤维化发生发展中的作用
The Role of Pericytes in the Development of Myocardial Fibrosis
论文作者
论文导师 任立群,论文学位 硕士,论文专业 医学生物工程
论文单位 吉林大学,点击次数 64,论文页数 54页File Size1772K
2006-10-20论文网 http://www.lw23.com/lunwen_949154402/
myocardial fibrosis; pericytes; extracellular matrix
心肌纤维化(myocardial fibrosis, MF)是各种心肌损害的被动结局,可引起心功能障碍,心率失常,甚至猝死。主要表现为间质中胶原沉积增多,其形成是一个缓慢的动态过程,涉及到包括细胞、细胞因子和细胞外基质(extracellular matrix, ECM)蛋白等多种因素。无论何种原因引起的心肌损害,只要病变持续和病程慢性化,终将导致心肌纤维化,其后果是难治性心衰和心律失常。 近年来关于ECM的生物学研究表明,在器官纤维化的形成过程中,往往有一些间质效应细胞发挥关键作用,它们的激活已成为胶原生成细胞的主要来源。心肌间质细胞中是否有像肝星状细胞、肾小球系膜细胞、胰腺星状细胞等那样的间质效应细胞至今还未确定。参与心肌纤维化的间质细胞种类很多,主要是肌成纤维细胞(myofibroblast,MFB)、成纤维细胞(cardial fibroblasts,cFb)等。有资料表明在心肌损伤修复处MFB是生成胶原的主要细胞类型,以至被称为瘢痕性MFB(scar myofibroblasts)。但正常情况下,MFB仅存在于心瓣膜,在心肌间质中很少见到。cFb或MFB均属于终末分化细胞,它们由什么细胞分化而来、位于何处,其生物学特性如何?这些问题迄今文献中未见提及。由于心肌间质中的周细胞的存在部位与前述肝、胰等的星状细胞及肾小球系膜细胞一致;而我们在缺血性心肌损害病例中,观察到小血管周围这类细胞的活跃增生,而且心肌间质性纤维化经常从小血管周围开始。因此,我们推测周细胞很可能是心肌纤维化中的主要间质效应细胞。确定周细胞是心肌纤维化发生发展中的主要
Myocardial fibrosis (MF) is the passive results of various kinds of myocardial damage, which can induce cardiac dysfunction, arrhythmia, and even sudden death. Its main manifestation is collagen deposition in matrix and its formation is a slow dynamic process involving many factors such as cell, cytokine, extracellular matrix(ECM)and so on. As long as the process is persistent and chronic, myocardial damage caused by any reason would induce MF of which results are refractoriness and arrhythmia in the end. In recent years, bioresearch about ECM indicated that there some kinds of matrix effector cells play key roles in the formation of organic fibrosis and the activation of them is the main source of collagenation cells. Whether there is a kind of matrix effector cells just like hepatic stellate cells, Mesangial cells, and pancreatic stellate cells in myocardial interstitial cells is not sure. There are many kinds of myocardial interstitial cells participate the process of MF, including myofibroblasts(MFB),cardial fibroblasts(cFb)and so on. Some documents indicated that MFB is the main collagenation cells in myocardial damage region as to MFB is called scar myofibroblasts. However, MFB only reside in heart valve and seldom appeared in myocardial interstitium on normal condition. cFb and MFB are both terminally differentiated cells . What kind of cell do they differentiate from? Where are they? What about their bionomics? These questions were not mentioned until now. The location of pericytes in
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